Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues. - Archive ouverte HAL Access content directly
Journal Articles Ecotoxicology and Environmental Safety Year : 2008

Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues.

Abstract

In an experimental food chain, Wistar rats were fed cadmium (Cd) in an inorganic (CdCl(2)) or organic (mainly associated with metallothionein from Helix aspersa snail viscera) form. After 1 month of exposure to 100 microg inorganic Cd g(-1) in food, an induction of metallothionein was observed in all target tissues. In liver, glutathione peroxidase (GSH-Px) activity decreased and alanine aminotransferase (ALAT) activity increased, suggesting that Cd causes hepatotoxicity. However, lipid peroxidation as well as catalase and caspase 3 (a marker of apoptosis) activities were not modified. At a rather low exposure (2.5 microg Cd g(-1)), metallothionein level in the kidney was found to be the most sensitive biomarker of exposure for both Cd forms. In the small intestine of rats ingesting inorganic Cd, metallothionein expression was significantly higher than that observed for rats fed organic Cd. Present results allowed proposing a simple design to assess the effect of a chemical in a trophic transfer approach.

Dates and versions

hal-00374583 , version 1 (09-04-2009)

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Cite

F. Hispard, Annette De Vaufleury, H. Martin, S. Devaux, R. P. Cosson, et al.. Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues.. Ecotoxicology and Environmental Safety, 2008, 70 (3), pp.490-8. ⟨10.1016/j.ecoenv.2007.04.005⟩. ⟨hal-00374583⟩
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