Article Dans Une Revue Science Année : 2003

Dual activation of the Drosophila toll pathway by two pattern recognition receptors

Résumé

The Toll- dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 ( GNBP1 ) gene and leads to compromised survival of mutant flies after Gram-positive infections, but not after fungal or Gram-negative bacterial challenge. Our results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway. The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects.

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hal-00311257 , version 1 (28-11-2024)

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Vanessa Gobert, Marie Gottar, Alexey Matskevich, Sophie Rutschmann, Julien Royet, et al.. Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science, 2003, 302 (5653), pp.2126-2130. ⟨10.1126/science.1085432⟩. ⟨hal-00311257⟩
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