Synthesis, chekpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles
Résumé
In the course of structure–activity relationship studies on granulatimide analogues, new pyrrolo[3,4-c]carbazoles have been synthesized in which the imidazole heterocycle was replaced by a five-membered ring lactam system or a dimethylcyclopentanedione. Moreover, the synthesis of an original structure in which a sugar moiety is attached to the indole nitrogen and to a six-membered D ring via an oxygen is reported. The inhibitory activities of the newly synthesized compounds toward checkpoint kinase 1 and their in vitro antiproliferative activities toward three tumor cell lines: murine leukemia L1210, and human colon carcinoma HT29 and HCT116 are described
Domaines
Chimie thérapeutique| Origine | Fichiers produits par l'(les) auteur(s) |
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