Rapid assembly of the polyhydroxylated b-amino acid constituents of microsclerodermins C, D et E.
Résumé
A very short and efficient synthesis of protected derivatives of APTO and AETD, the complex polyhydroxylated -amino acid residues present in microsclerodermins C, D, and E, is described. The targets are obtained in only five steps, in 23% and 16% overall yields, respectively. The key transformation involves the completely diastereoselective two-carbon homologation of appropriately selected intermediate chiral sulfinimines
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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