A short and versatile route to chiral spiroketal skeletons
Résumé
Different chiral spiroketal skeletons are obtained, in a versatile manner, by iterative alkylations of acetone N,N-dimethylhydrazone with iodides 2 followed by a one-pot deprotection/spirocyclization sequence. This methodology has been applied successfully to the synthesis of 1,7-dioxaspiro[5.5]undecane and 1,6-dioxaspiro[4.5]decane systems
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
|---|