Chemoenzymatic synthesis of 5-thio-D-xylopyranose. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2006

Chemoenzymatic synthesis of 5-thio-D-xylopyranose.

Résumé

5-thio-D-xylopyranose, a synthon used for the preparation of drugs with antithrombotic activity, was synthesised by an enzymatic isomerisation from the corresponding ketose, 5-thio-D-xylulofuranose, with glucose isomerase. This compound was obtained by two different chemoenzymatic routes, the key step being the stereospecific formation of a C-C bond, catalysed by transketolase or fructose-1,6-bisphosphate aldolase

Domaines

Chimie organique
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Dates et versions

hal-00121152 , version 1 (26-02-2007)

Identifiants

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Franck Charmantray, Philippe Dellis, Virgil Hélaine, Soth Samreth, Laurence Hecquet. Chemoenzymatic synthesis of 5-thio-D-xylopyranose.. European Journal of Organic Chemistry, 2006, pp.5526-5532. ⟨10.1002/ejoc.200600627⟩. ⟨hal-00121152⟩
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