Chemoenzymatic synthesis of 5-thio-D-xylopyranose.
Résumé
5-thio-D-xylopyranose, a synthon used for the preparation of drugs with antithrombotic activity, was synthesised by an enzymatic isomerisation from the corresponding ketose, 5-thio-D-xylulofuranose, with glucose isomerase. This compound was obtained by two different chemoenzymatic routes, the key step being the stereospecific formation of a C-C bond, catalysed by transketolase or fructose-1,6-bisphosphate aldolase
Domaines
Chimie organique| Origine | Fichiers produits par l'(les) auteur(s) |
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