Prediction of high-cycle fatigue resistance is of great importance for structural design. In spite of this clear industrial need, until now modeling of metal behavior in a high-cycle fatigue regime was often based on empirical approaches: the Wöhler curve and the Goodman-Haigh or Gerber diagrams are still the very popular tools for engineers. However, these concepts are not appropriate when studying the multiaxial stress cycles that are frequently encountered on modem mechanical components. These multiaxial stresses arise from factors such as external loadings, the geometry of the structure, which can induce multiaxiality even if the loading is uniaxial, and finally residual stresses.