Well-posedness of a parabolic problem based on a bidomain model for electrophysiological wave propagation - Archive ouverte HAL
Pré-Publication, Document De Travail Année : 2006

Well-posedness of a parabolic problem based on a bidomain model for electrophysiological wave propagation

Résumé

The purpose of the current paper is to study the well-posedness of the bidomain model. That model is commonly used to simulate electrophysiological wave propagation in the heart. We base our analysis on a formulation of the bidomain model describing two potentials that satisfy a system of coupled parabolic and elliptic PDEs, these being coupled with one or more ODEs representing the ionic activity. The parabolic and elliptic PDEs are first converted into a single parabolic PDE by the introduction of the so-called bidomain operator. We properly define and analyze that bidomain operator. We then present a proof of existence, uniqueness and regularity of a local (in time) solution through a semi-group approach. The bidomain model is next reformulated as a parabolic variational problem, through the introduction of a bidomain bilinear form. A proof of existence and uniqueness of a global solution is obtained using a compactness argument, this time for an ionic model reading as a single ODE but including polynomial nonlinearities. Finally, the hypothesis behind the existence of that global solution are verified for three commonly used ionic models, namely the FitzHugh-Nagumo, Aliev-Panfilov and MacCulloch models.
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Dates et versions

hal-00101458 , version 1 (27-09-2006)
hal-00101458 , version 2 (25-05-2007)

Identifiants

  • HAL Id : hal-00101458 , version 1

Citer

Yves Bourgault, Yves Coudière, Charles Pierre. Well-posedness of a parabolic problem based on a bidomain model for electrophysiological wave propagation. 2006. ⟨hal-00101458v1⟩
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