In the last few years, many works have been done in order to ensure interoperability between applications. Enterprise applications integration and the opening of information systems towards integrated access have been the main motivation for the interest around systems interoperability. In this Paper, an MDA based approach for interoperability is proposed. The MDA is an approach for systems development, which increases the power of models in that work. It provides a means for using models for better understanding, designing, constructing, deploying, operating, maintaining and modifying systems. The three primary goals of MDA are portability, interoperability and reusability. In this paper we apply the MDA as a formal base that supports our approach for interoperability between different information systems