The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.

Keywords

2019-nCoV Antivirals Furin Maturation protease SARS-CoV Spike protein

Domains

Structural Biology [q-bio.BM] Virology Emerging diseases

Embargoed file

Visibility date is undetermined

Myriam Bodescot : Connect in order to contact the contributor

https://inserm.hal.science/inserm-02517696

Submitted on : Thursday, May 28, 2020-11:11:51 AM

Last modification on : Friday, September 6, 2024-5:36:04 PM

Dates and versions

inserm-02517696 , version 1 (28-05-2020)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

HAL Id : inserm-02517696 , version 1
DOI : 10.1016/j.antiviral.2020.104742
PUBMED : 32057769
WOS : 000523597500019

Cite

Bruno Coutard, Coralie Valle, Xavier de Lamballerie, Bruno Canard, Nabil G Seidah, et al.. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research, 2020, 176, pp.104742. ⟨10.1016/j.antiviral.2020.104742⟩. ⟨inserm-02517696⟩

Export

BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite

Collections

INSERM IRD CNRS UNIV-AMU INRAE AFMB MICA-UNITES INRAEPACA

350 View

1 Download