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Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design

Fatiha Benmansour , Iuni Trist , Bruno Coutard , Etienne Decroly , Gilles Querat , et al.
European Journal of Medicinal Chemistry, 2017, 125, pp.865-880. ⟨10.1016/j.ejmech.2016.10.007⟩
Journal articles hal-02061703v1

Toscana virus nucleoprotein oligomer organization observed in solution

Amal Baklouti , Adeline Goulet , Julie Lichiere , Bruno Canard , Remi Charrel , et al.
Acta crystallographica Section D : Structural biology [1993-..], 2017, 73 (8), pp.650 - 659. ⟨10.1107/S2059798317008774⟩
Journal articles hal-01802854v1

Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering

Nicolas Papageorgiou , Julie Lichiere , Amal Baklouti , Francois Ferron , Marion Sevajol , et al.
Acta crystallographica Section D : Structural biology [1993-..], 2016, 72 (2), pp.192-202. ⟨10.1107/S2059798315024328⟩
Journal articles hal-01439080v1

Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights

Stavroula Fili , Alexandros Valmas , Magdalini Christopoulou , Maria Spiliopoulou , Nikos Nikolopoulos , et al.
Acta crystallographica Section F : Structural biology communications [2014-..], 2016, 72 (12), pp.877-884. ⟨10.1107/S2053230X16018513⟩
Journal articles hal-01439101v1

NMR study of non-structural proteins-part I: H-1, C-13, N-15 backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV)

Efstathios Melekis , Aikaterini C. Tsika , Julie Lichiere , Christos T. Chasapis , Irene Margiolaki , et al.
BIOMOLECULAR NMR ASSIGNMENTS, 2015, 9 (1), pp.191-195. ⟨10.1007/s12104-014-9572-0⟩
Journal articles hal-01438992v1

mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

Changqing Li , Jaime Guillen , Nadia Rabah , Alexandre Blanjoie , Francoise Debart , et al.
Journal of Virology, 2015, 89 (16), pp.8292-8303. ⟨10.1128/JVI.00599-15⟩
Journal articles hal-01439035v1
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Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

Nadia Rabah , Oney Ortega Granda , Gilles Quérat , Bruno Canard , Etienne Decroly , et al.
Antiviral Research, 2020, 182, pp.104883. ⟨10.1016/j.antiviral.2020.104883⟩
Journal articles hal-03030827v1
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Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Daniel L Hurdiss , Priscila El Kazzi , Lisa Bauer , Nicolas Papageorgiou , Francois Ferron , et al.
Science Advances , 2022, 8 (1), ⟨10.1126/sciadv.abj7615⟩
Journal articles hal-03572836v1

Expression, purification and crystallization of the SARS-CoV macro domain

Hélène Malet , Karen Dalle , Nicolas Bremond , Fabienne Tocque , Stéphanie Blangy , et al.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2006, 62 (4), pp.405-408. ⟨10.1107/S1744309106009274⟩
Journal articles hal-02066254v1
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The Cytotoxic Effect of Apis mellifera Venom with a Synergistic Potential of Its Two Main Components—Melittin and PLA2—On Colon Cancer HCT116 Cell Lines

Carole Yaacoub , Mariam Rifi , Dany El-Obeid , Hiba Mawlawi , Jean-Marc Sabatier , et al.
Molecules, 2021, 26 (8), pp.2264. ⟨10.3390/molecules26082264⟩
Journal articles hal-03358045v1
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Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Ashleigh Shannon , Barbara Selisko , Nhung-Thi-Tuyet Le , Johanna Huchting , Franck Touret , et al.
Nature Communications, 2020, 11 (1), pp.4682. ⟨10.1038/s41467-020-18463-z⟩
Journal articles inserm-03052188v1
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Snapshots of ADp-ribose bound to Getah virus macro domain reveal an intriguing choreography

Ana Sofia Ferreira-Ramos , Gerlind Sulzenbacher , Bruno Canard , Bruno Coutard
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-70870-w⟩
Journal articles hal-03160433v1
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High specificity and sensitivity of Zika EDIII-based ELISA diagnosis highlighted by a large human reference panel

Jessica Denis , Sarah Attoumani , Patrick Gravier , Bernard Tenebray , Annabelle Garnier , et al.
PLoS Neglected Tropical Diseases, 2019, 13 (9), pp.e0007747. ⟨10.1371/journal.pntd.0007747⟩
Journal articles inserm-02416987v1

Drugs against SARS‐CoV ‐2: What do we know about their mode of action?

Coralie Valle , Baptiste Martin , Franck Touret , Ashleigh Shannon , Bruno Canard , et al.
Reviews in Medical Virology, 2020, 30 (6), pp.1-10. ⟨10.1002/rmv.2143⟩
Journal articles hal-03030758v1
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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Bruno Coutard , Coralie Valle , Xavier de Lamballerie , Bruno Canard , Nabil G Seidah , et al.
Antiviral Research, 2020, 176, pp.104742. ⟨10.1016/j.antiviral.2020.104742⟩
Journal articles inserm-02517696v1
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The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

Lonneke van Der Linden , Laia Vives-Adrián , Barbara Selisko , Cristina Ferrer-Orta , Xinran Liu , et al.
PLoS Pathogens, 2015, 11 (UNSP e1004733), ⟨10.1371/journal.ppat.1004733.s010⟩
Journal articles hal-01219259v1
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The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

Baptiste Martin , Bruno Coutard , Théo Guez , Guido Paesen , Bruno Canard , et al.
Nucleic Acids Research, 2018, 46 (15), pp.7902-7912. ⟨10.1093/nar/gky637⟩
Journal articles inserm-02416986v1

Viral Macro Domains Reverse Protein ADP-Ribosylation

Changqing Li , Yannick Debing , Gytis Jankevicius , Johan Neyts , Ivan Ahel , et al.
Journal of Virology, 2016, 90 (19), pp.8478-8486. ⟨10.1128/JVI.00705-16⟩
Journal articles hal-01439096v1
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Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs

Baptiste Martin , Coralie Valle , Bruno Coutard , Bruno Canard , Françoise Debart , et al.
Médecine/Sciences, 2018, 34 (11), pp.919-921. ⟨10.1051/medsci/2018230⟩
Journal articles hal-02094423v1
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Antiviral activity of [1,2,3]triazolo[4,5- d ]pyrimidin-7(6 H )-ones against chikungunya virus targeting the viral capping nsP1

Alba Gigante , Asier Gómez-Sanjuan , Leen Delang , Changqing Li , Oskía Bueno , et al.
Antiviral Research, 2017, 144, pp.216-222. ⟨10.1016/j.antiviral.2017.06.003⟩
Journal articles hal-01802837v1

Single pH buffer refolding screen for protein from inclusion bodies

Bruno Coutard , Etienne Danchin , Rachid Oubelaid , Bruno Canard , Christophe Bignon
Protein Expression and Purification, 2012, 82 (2), pp.352-359. ⟨10.1016/j.pep.2012.01.014⟩
Journal articles istex hal-02649344v1
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Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection

Rami Sommerstein , Lukas Flatz , Melissa M. Remy , Pauline Malinge , Giovanni Magistrelli , et al.
PLoS Pathogens, 2015, 11 (11), ⟨10.1371/journal.ppat.1005276⟩
Journal articles hal-01439028v1
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Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

Jessica Hernandez , Laurent Hoffer , Bruno Coutard , Gilles Quérat , Philippe Roche , et al.
European Journal of Medicinal Chemistry, 2019, 161 (4), pp.323-333. ⟨10.1016/j.ejmech.2018.09.056⟩
Journal articles inserm-02378768v1
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Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose

Garyfallia Makrynitsa , Dioni Ntonti , Konstantinos Marousis , Maria Birkou , Minos-Timotheos Matsoukas , et al.
Journal of Structural Biology, 2019, 206 (1), pp.119-127. ⟨10.1016/j.jsb.2019.02.008⟩
Journal articles inserm-02416973v1

Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5′ End

Oney Ortega Granda , Coralie Valle , Ashleigh Shannon , Etienne Decroly , Bruno Canard , et al.
Journal of Virology, 2021, 95 (15), ⟨10.1128/JVI.00777-21⟩
Journal articles hal-03426112v1
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Comparative study of chikungunya Virus-Like Particles and Pseudotyped-Particles used for serological detection of specific immunoglobulin M

Gérald Theillet , Jérôme Martinez , Christophe Steinbrugger , Dimitri Lavillette , Bruno Coutard , et al.
Virology, 2019, 529, pp.195-204. ⟨10.1016/j.virol.2019.01.027⟩
Journal articles inserm-02374934v1
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Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner

Lisa Bauer , Roberto Manganaro , Birgit Zonsics , Jeroen Strating , Priscila El Kazzi , et al.
ACS Infectious Diseases, 2019, 5 (9), pp.1609-1623. ⟨10.1021/acsinfecdis.9b00179⟩
Journal articles inserm-02416968v1
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First insights into the structural features of Ebola virus methyltransferase activities

Coralie Valle , Baptiste Martin , François Ferron , Véronique Roig-Zamboni , Aline Desmyter , et al.
Nucleic Acids Research, 2021, 49 (3), pp.1737 - 1748. ⟨10.1093/nar/gkaa1276⟩
Journal articles hal-03334409v1

Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

Bruno Coutard , Etienne Decroly , Changqing Li , Andrew Sharff , Julien Lescar , et al.
Antiviral Research, 2014, 106, pp.61-70. ⟨10.1016/j.antiviral.2014.03.013⟩
Journal articles hal-02061701v1
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Development and Evaluation of a duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding Regions

Laura Pezzi , Remi Charrel , Laetitia Ninove , Antoine Nougairede , Gregory Molle , et al.
Viruses, 2020, 12 (6), pp.686. ⟨10.3390/v12060686⟩
Journal articles hal-02897091v1