Two well-dated ca Holocene-long sedimentary sequences from deepest parts of Lake Bourget provide new insights onto the evolution of erosion patterns at a regional scale in NW European Alps. The combination of high resolution geochemistry e XRF core scanning, calibrated by 150 punctual measurements e and isotope geochemistry ( 3Nd) of the terrigenous fraction permitted the reconstruction not only of the intensity, but also the type (physical erosion vs. chemical weathering) and the location (Prealpine massifs vs. High Crystalline massifs) of dominant erosion processes. Those data point the persistency of weak erosion fluxes from 9600 to 5500 cal. BP due both to a dry climate and the growing sheltering effect of soils that rapidly progressed between 9600 and 8000 cal. BP. Soils then reached a steady state before being destabilised around 4400 cal. BP, probably in response to human impact. The human impact then reached a sufficient intensity to change erosion patterns at a regional scale, but did not result in a significant increase of the regional terrigenous flux. The following enhancement of erosion processes occurred around 2700 cal. BP. It was first paced by changing climatic conditions, but probably reinforced by human impact during Late Iron Age e Antiquity period. Over the long-term trend, the Lake Bourget record pinpoints an evolution of paleohydrological conditions in the Alps dominated by dry conditions from 9500 to 4400 cal. BP and a subsequent drift toward wetter conditions that culminated during the so-called Little Ice Age (ca 1350e1900 AD). In such a context the current dry conditions in European Alps appear out-of-trend. At high resolution, 17 periods of enhanced hydrological activity highlight the rapid climatic changes that are typical of the Holocene.