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Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2011

Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni.

Résumé

Trioxaquine PA1259 is an efficient drug on larval- and adult-stage schistosomes, able to alkylate heme inside the treated worms, leading to the formation of covalent heme-drug adducts. Such mechanism, similar to that one reported for other trioxaquines in Plasmodium, indicates that heme may be a common target of these trioxane-based drugs in different blood-feeding parasites.

Dates et versions

halsde-00580767 , version 1 (29-03-2011)

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Citer

Vincent Pradines, Julien Portela, Jérôme Boissier, Frédéric Coslédan, B. Meunier, et al.. Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni.. Antimicrobial Agents and Chemotherapy, 2011, 55 (5), pp.2403-2405. ⟨10.1128/AAC.00082-11⟩. ⟨halsde-00580767⟩
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