Article Dans Une Revue (Data Paper) Science Advances Année : 2025

Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin

Simon Léonard
Adèle Mauroux
Thomas Darde
  • Fonction : Auteur

Résumé

Emerging evidence demonstrates that self-reactive CD8 + T resident memory cells (T RM cells) may already populate the never-lesional (NL) skin of patients with chronic inflammatory conditions, including vitiligo. However, their functional activity and regulation remain unknown. By combining cellular and transcriptomic approaches, we show that common CD8 + T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional (PL) skin of patients with vitiligo. Pathways related to immune activation were more active in T cells from PL skin, while those related to immune regulation were enriched in NL skin T cells, also evidenced by the stronger infiltration of regulatory T cells and the higher expression of programmed cell death protein 1 (PD-1) by CD8 + T cells in NL skin. Treatment of patients with baricitinib led to an increase in regulatory T cells and CD8 + T cells expressing PD-1 in repigmented skin. These findings suggest that functional T cells populate pigmented skin in vitiligo and highlight the importance of regulatory mechanisms to restrain their activation and prevent depigmentation.

Dates et versions

hal-05603943 , version 1 (27-04-2026)

Identifiants

Citer

Laure Migayron, Ribal Merhi, Chloé Avril, Simon Léonard, Atika Zouine, et al.. Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin. Science Advances , 2025, 11 (50), pp.eadu9360. ⟨10.1126/sciadv.adu9360⟩. ⟨hal-05603943⟩
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