Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin
2 R&D Department, SILAB
3 Hôpital Saint-André [Bordeaux]
4 SciLicium [Rennes]
5 UAR3427 - INSERM US005 - TBM-Core [Bordeaux]
6 AP-HP - Hopital Saint-Louis [AP-HP]
7 HIPI (UMR_S_976 / U976) - Immunologie humaine, physiopathologie & immunothérapie
8 LITEC [Poitiers] - Laboratoire inflammation, tissus épithéliaux et cytokines [UR 15560]
9 Explicyte Immuno-Oncology [Bordeaux]
10 SciLicium
- Fonction : Auteur
- PersonId : 1673903
- ORCID : 0000-0003-2003-1923
- Fonction : Auteur
- PersonId : 1673904
- ORCID : 0009-0002-8662-5089
- Fonction : Auteur
- PersonId : 1170025
- ORCID : 0000-0002-6706-7424
- Fonction : Auteur
- PersonId : 1673905
- ORCID : 0009-0001-5501-4747
- Fonction : Auteur
- PersonId : 1679913
- IdRef : 259432784
- Fonction : Auteur
- PersonId : 1315239
- ORCID : 0000-0002-9933-6879
- Fonction : Auteur
- PersonId : 1414433
- ORCID : 0000-0002-3993-0956
- Fonction : Auteur
- PersonId : 758625
- ORCID : 0000-0002-9283-1068
- IdRef : 139191690
- Fonction : Auteur
- PersonId : 1667931
- ORCID : 0000-0003-4428-1222
Résumé
Emerging evidence demonstrates that self-reactive CD8 + T resident memory cells (T RM cells) may already populate the never-lesional (NL) skin of patients with chronic inflammatory conditions, including vitiligo. However, their functional activity and regulation remain unknown. By combining cellular and transcriptomic approaches, we show that common CD8 + T cell clusters with a similar transcriptional profile infiltrate NL and peri-lesional (PL) skin of patients with vitiligo. Pathways related to immune activation were more active in T cells from PL skin, while those related to immune regulation were enriched in NL skin T cells, also evidenced by the stronger infiltration of regulatory T cells and the higher expression of programmed cell death protein 1 (PD-1) by CD8 + T cells in NL skin. Treatment of patients with baricitinib led to an increase in regulatory T cells and CD8 + T cells expressing PD-1 in repigmented skin. These findings suggest that functional T cells populate pigmented skin in vitiligo and highlight the importance of regulatory mechanisms to restrain their activation and prevent depigmentation.