Article Dans Une Revue Medical Mycology Année : 2026

A decade of ocular fungal infections due to <i>Penicillium</i> -like fungi in France (2012 to 2021)

1 DYNAMIC - Dynamic Microbiology - EA 7380
2 CHU Henri Mondor [Créteil]
3 Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris]
4 CNRMA - Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals
5 Mycologie translationnelle - Translational Mycology
6 Service des Maladies infectieuses et tropicales [CHU Necker]
7 CHNO - Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
8 CHU Amiens-Picardie
9 CHU Angers - Centre Hospitalier Universitaire d'Angers
10 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
11 LCE - Laboratoire Chrono-environnement (UMR 6249)
12 CRCTB - Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
13 CHU Caen Normandie - CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie
14 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
15 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
16 PAM - Procédés Alimentaires et Microbiologiques [Dijon]
17 Hôpital Foch [Suresnes]
18 CHU de Martinique - Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique]
19 CHU Pointe-à-Pitre / Abymes [Guadeloupe]
20 CHU Montpellier = Montpellier University Hospital
21 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
22 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
23 Laboratoire de Parasitologie-Mycologie [CHU Saint Louis, Paris]
24 Centre Hospitalier Universitaire [Rennes]
25 Irset - Institut de recherche en santé, environnement et travail
26 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle
27 HUS - Hôpitaux Universitaires de Strasbourg
28 CHU La Réunion - Centre Hospitalier Universitaire de La Réunion
29 PIMIT - Processus Infectieux en Milieu Insulaire Tropical
30 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
31 IICiMed - Cibles et Médicaments des Infections et de l'Immunité - UR 1155
32 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
33 Hôpital Henri Mondor
Taieb Chouaki
Emilie Cardot Martin
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Résumé

Penicillium, Talaromyces, and Purpureocillium species (so called Penicillium-like) are increasingly recognised as opportunistic fungal pathogens capable of causing a wide range of infections, from superficial to invasive. Although ocular infections caused by these environmental fungi have been reported in the literature, they remain relatively underrecognised. We conducted a multicentric retrospective study of Penicillium-like ocular cases reported in the RESSIF database of the French National Reference Center for Invasive Mycoses and Antifungals between 2012 to 2021. Among 55 cases of Penicillium-like invasive infections reported to the RESSIF network in France, a total of 24 cases (44%) were identified, which predominantly presented as keratitis (n = 22, 92%). Predisposing factors were as follows: contact lens wear (n = 11, 46%), topical corticosteroid use (n = 9, 37.5%), ocular trauma (n = 5, 21%), pre-existing corneal disease (n = 4, 17%), and previous ocular surgery (n = 2, 8%). Purpureocillium lilacinum was the predominant pathogen (n = 19, 79%), followed by four Penicillium species and one Talaromyces species. Direct examination of ocular samples was positive in 13 cases (54%). Antifungal susceptibility testing (EUCAST) revealed that all species exhibited high minimal inhibitory concentrations to amphotericin B (&amp;gt;1 mg/L). Most patients were treated with a combination of topical voriconazole and amphotericin B (n = 15, 62.5%), which was administered alongside oral voriconazole in nine cases (37.5%). Surgical intervention was required in six cases (25%) and included keratoplasty (n = 4) and enucleation (n = 2). This study provides a valuable overview of Penicillium-like fungal ocular infections and highlights the importance of systematically surveilling filamentous fungal keratitis.

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Dates et versions

hal-05582841 , version 1 (07-04-2026)

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Lorra Monpierre, Eric Dannaoui, Olivier Lortholary, Karine Boukris-Sitbon, Lilia Merabet, et al.. A decade of ocular fungal infections due to <i>Penicillium</i> -like fungi in France (2012 to 2021). Medical Mycology, 2026, 64 (4), pp.myag025. ⟨10.1093/mmy/myag025⟩. ⟨hal-05582841⟩
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