Article Dans Une Revue FEBS Letters Année : 1998

Cysteine‐string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes

Résumé

Cysteine‐string proteins (Csps) are vesicle proteins involved in exocytosis of synaptic vesicles in Drosophila and modulation of presynaptic calcium influx. As both the contribution of calcium channel regulation to the role of Csp in exocytosis and a function of Csp outside the nervous system are unknown, we studied its function in endocrine exocytosis from large dense core vesicles (LDCVs) using insulin‐secreting pancreatic β‐cells. Csps were expressed in primary and derived β‐cell lines on insulin‐containing LDCVs. Suppression of Csp expression reduced not only depolarisation induced insulin release but also exocytosis in permeabilised cells directly stimulated by Ca 2+ . Thus, Csp is a secretory granule protein and is required for endocrine exocytosis independent of the modulation of transmembrane calcium fluxes.

Dates et versions

hal-05545824 , version 1 (10-03-2026)

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Citer

Hui Zhang, William Kelley, Luke Chamberlain, Robert Burgoyne, Claes Wollheim, et al.. Cysteine‐string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes. FEBS Letters, 1998, 437 (3), pp.267-272. ⟨10.1016/s0014-5793(98)01233-2⟩. ⟨hal-05545824⟩
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