Article Dans Une Revue Clinical Chemistry and Laboratory Medicine Année : 2026

Multi-analytical identification of the synthetic opioids cychlorphine and methiodone (IC-26) in drug seizures: first detection in Europe

Marie Bellouard
Sevag Chenorhokian
  • Fonction : Auteur
Maxime Triguel
  • Fonction : Auteur
Cindy Feng
  • Fonction : Auteur
Sabrina Cherki
  • Fonction : Auteur

Résumé

Abstract Objectives The rapid emergence of highly potent synthetic opioids represents a growing challenge for forensic and clinical laboratories. Methods We report the first identification in Europe of methiodone (IC-26) and the first detection in France of cychlorphine in drug samples collected by a drug-checking service in Paris. Results Preliminary screening by liquid chromatography with diode-array detection (LC-DAD) and gas chromatography coupled with mass spectrometry (GC-MS) revealed unknown peaks due to the lack of corresponding spectra in available spectral librairies. High-resolution mass spectrometry (LC-HRMS) provided accurate mass measurements consistent with the cychlorphine and Methiodone formulas. Structural confirmation was obtained by 1D/2D nuclear magnetic resonance (NMR) spectroscopy. Targeted LC-MS/MS quantified 5 % cychlorphine and 2 % methiodone, with no other psychoactive compounds detected. Conclusions These results highlight the limitations of library-based screening and the value of multi-platform strategies integrating LC-HRMS, LC-MS/MS, and NMR for the early detection of emerging drugs.

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Dates et versions

hal-05467098 , version 1 (20-01-2026)

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Citer

Paméla Dugues, Tiphaine Robin, Marie Bellouard, Sevag Chenorhokian, Maxime Triguel, et al.. Multi-analytical identification of the synthetic opioids cychlorphine and methiodone (IC-26) in drug seizures: first detection in Europe. Clinical Chemistry and Laboratory Medicine, 2026, ⟨10.1515/cclm-2025-1428⟩. ⟨hal-05467098⟩
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