Article Dans Une Revue European Journal of Neuroscience Année : 2002

Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition

Résumé

Abstract This paper focuses on high‐frequency (gamma band) EEG activity, the most characteristic electrophysiological pattern in focal seizures of human epilepsy. It starts with recent hypotheses about: (i) the behaviour of inhibitory interneurons in hippocampal or neocortical networks in the generation of gamma frequency oscillations; (ii) the nonuniform alteration of GABAergic inhibition in experimental epilepsy (reduced dendritic inhibition and increased somatic inhibition); and (iii) the possible depression of GABA A,fast circuit activity by GABA A,slow inhibitory postsynaptic currents. In particular, these hypotheses are introduced in a new computational macroscopic model of EEG activity that includes a physiologically relevant fast inhibitory feedback loop. Results show that strikingly realistic activity is produced by the model when compared to real EEG signals recorded with intracerebral electrodes. They show that, in the model, the transition from interictal to fast ictal activity is explained by the impairment of dendritic inhibition.

Dates et versions

hal-05416832 , version 1 (15-12-2025)

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Fabrice Wendling, F. Bartolomei, J. Bellanger, P. Chauvel. Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition. European Journal of Neuroscience, 2002, 15 (9), pp.1499-1508. ⟨10.1046/j.1460-9568.2002.01985.x⟩. ⟨hal-05416832⟩
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