Article Dans Une Revue Journal of Neurology Année : 2024

Recognition memory decline is associated with the progression to prodromal Alzheimer’s disease in asymptomatic at-risk individuals

Katia Andrade

Résumé

Episodic memory (EM) alterations are a hallmark of Alzheimer's disease (AD). We assessed EM longitudinally in cognitively normal elders at-risk for AD (with subjective memory complaints), as a function of amyloid-β (Aβ) burden, neurodegeneration (N), and progression to prodromal AD. We stratified 264 INSIGHT-preAD study subjects in controls (Aβ-/N-), stable/ N-or N + (Aβ +), and progressors/N-or N + (Aβ +) groups (progressors were included only until AD-diagnosis). We used linear mixed-effect models with Aβ and N status, or progression to AD as factors, to analyze behavioral performance in an old/new word-recognition task based on the free and cued selective reminding test (FCSRT). The controls and stable/ N-groups showed near-ceiling accuracy and RT improvement across follow-up. The stable/N + group showed accuracy reduction and no RT improvement, i.e., Aβ + /N + cumulative effect. The progressors showed a marked performance decline. EM alterations may constitute early preclinical markers of progression to prodromal AD, while individuals are cognitively normal according to neuropsychological standards.

Fichier principal
Vignette du fichier
RaposoPereira_INSIGHT_OldNew_BehavPaper_JNeurol24_wSuppl.pdf (3.73 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-05405398 , version 1 (08-12-2025)

Licence

Identifiants

Citer

Filipa Raposo Pereira, Maximilien Chaumon, Bruno Dubois, Hovagim Bakardjian, Mahsa Bahrami, et al.. Recognition memory decline is associated with the progression to prodromal Alzheimer’s disease in asymptomatic at-risk individuals. Journal of Neurology, 2024, 272 (70), ⟨10.1007/s00415-024-12834-y⟩. ⟨hal-05405398⟩
320 Consultations
176 Téléchargements

Altmetric

Partager

  • More