Brain monoamine concentrations in three genetic models of depression
Résumé
Three lines of “helpless” mice, called H/Rouen, H/TST and H/FST with different genetic backgrounds were developed by selective breeding from their long duration immobility in the tail suspension test (H/Rouen and H/TST) or in the forced- swim test (H/FST). In order to investigate whether brain monoaminergic systems could be involved in the mechanism of depressive behaviors exhibited by these animals, monoamines and metabolites contents were determined by HPLC with electrochemical detection in brain areas from adult H/Rouen, H/TST and H/FST female mice and compared to their respective “non-helpless” control. These data strongly suggest that the involvement of brain dopaminergic, noradrenergic and serotoninergic systems may be different in these three genetic models of depression. In H/Rouen animals NA metabolism may be higher in the prefrontal cortex and decreased in the hypothalamus, while 5-HT metabolism is lowered in the prefrontal cortex and the striatum. In H/TST animals, 5-HT metabolism is lowered in the prefrontal cortex, hippocampus and striatum, while DA metabolism is decreased in the striatum. In contrast, H/FST animals exhibit enhanced 5-HT metabolism in the prefrontal cortex, striatum and hypothalamus.
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