Poster De Conférence Année : 2022

Iron deficiency in cystic fibrosis: a prospective study in a modern adult cohort

Résumé

Objectives: Iron homeostasis is a crucial issue in cystic fibrosis (CF) because of its close relationship with Pseudomonas aeruginosa colonisation. Irondeficiency (ID) diagnosis in CF is challenging because of frequent systemicinflammation. We aimed to determine the prevalence and risk factors of ID in adult patients with CF. Methods: A monocentric prospective study was performed in a referral centre for adult CF patients. Clinical and biological parameters were collected during the annual medical check-up. Apparent exacerbation was an exclusion criterion. ID was defined by transferrin saturation ≤16% orferritin ≤20 (women) or 30 (men) μg/L or ≤100 μg/L in the case of significant systemic inflammation. Results: We included 165 patients (78 women), mean age 31.1 ± 8.9 years.ID prevalence was 44.2%. Univariate analysis showed a significant association of ID with female gender (58.9% vs 38%), lower age (29.4 ± 8.5vs 32.5 ± 9.1), lower body-mass-index (20.5 ± 2.2 vs 21.3 ± 2.5) and Pseudomonas aeruginosa colonisation (70.8% versus 55.1%). Diabetes mellitus, antiacid drug-use and low pulmonary function were more frequent in patients with ID with no statistical significance. Use of CFTR correctors and soluble vitamin deficiency was not associated with ID. In themultivariate analysis, ID was associated with female gender (OR 2.64,CI95% 1.31–5.31), age <30 years (OR 2.30, CI95% 1.16–4.56) and P.aeruginosa (OR 2.09, CI95% 1.04–4.19). Conclusion: ID is highly prevalent in adult patients with CF. The main risk factors are female gender, younger age, low BMI and Pseudomonasaeruginosa.

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Dates et versions

hal-05399022 , version 1 (04-12-2025)

Identifiants

  • HAL Id : hal-05399022 , version 1

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Hervé Lobbes, Stéphane Durupt, Bruno Pereira, Sabine Mainbourg, Raphaele Nove-Josserand, et al.. Iron deficiency in cystic fibrosis: a prospective study in a modern adult cohort. 45th European Cystic Fibrosis Conference, Jun 2022, Rotterdam (NL), Netherlands. ⟨hal-05399022⟩
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