Decoding the mechanism for cytotoxicity in thiolato-bridged triosmium carbonyl clusters: from serum reactivity to cellular impact
Résumé
Mechanism of action (MoA) studies on the cytotoxic thiolato-bridged triosmium carbonyl clusters Os3(CO)10(μ-H)(μ-SR) (2) indicate that their cytotoxicity is associated with increased reactive oxygen species (ROS) generation, G2/M cell cycle arrest, and subsequent apoptosis. Cellular uptake is a key factor, with an increased reactivity of the cluster with serum leading to reduced available concentrations in the medium thereby diminishing its antiproliferative effect. Reactivity studies reveal that biomolecular interactions occur predominantly at the triosmium core, with a preference for amine-containing species.
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