Pré-Publication, Document De Travail Année : 2025

Indanone Building Blocks from Lignin Related C-9 Plaform Molecules

Résumé

Lignin-based aryl 3-hydroxypropanones were converted into indanones via domino dehydration/Nazarov cyclization in the presence of a superacid. The cyclization was studied in detail, and the resulting indanones were engaged in two postfunctionalizations: a reduction/elimination domino sequence and a ring expansion. Lastly, the method has been successfully applied to the synthesis of the anti-Alzheimer drug donepezil.

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Dates et versions

hal-05349332 , version 1 (05-11-2025)

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Josue Arturo Ledezma Fierro, Simona G Bassoli, Julian A Schilke, Anett Schallmey, Giovanni Poli, et al.. Indanone Building Blocks from Lignin Related C-9 Plaform Molecules. 2025. ⟨hal-05349332⟩
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