Article Dans Une Revue Nature Communications Année : 2023

Acute stress induces long-term metabolic, functional, and structural remodeling of the heart

Elie Mousseaux

Résumé

Takotsubo cardiomyopathy is a stress-induced cardiovascular disease with symptoms comparable to those of an acute coronary syndrome but without coronary obstruction. Takotsubo was initially considered spontaneously reversible, but epidemiological studies revealed significant long-term morbidity and mortality, the reason for which is unknown. Here, we show in a female rodent model that a single pharmacological challenge creates a stress-induced cardiomyopathy similar to Takotsubo. The acute response involves changes in blood and tissue biomarkers and in cardiac in vivo imaging acquired with ultrasound, magnetic resonance and positron emission tomography. Longitudinal follow up using in vivo imaging, histochemistry, protein and proteomics analyses evidences a continued metabolic reprogramming of the heart towards metabolic malfunction, eventually leading to irreversible damage in cardiac function and structure. The results combat the supposed reversibility of Takotsubo, point to dysregulation of glucose metabolic pathways as a main cause of long-term cardiac disease and support early therapeutic management of Takotsubo.

Fichier principal
Vignette du fichier
s41467-023-39590-3.pdf (5.48 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-05345765 , version 1 (04-11-2025)

Licence

Identifiants

Citer

Thulaciga Yoganathan, Mailyn Perez-Liva, Daniel Balvay, Morgane Le Gall, Alice Lallemand, et al.. Acute stress induces long-term metabolic, functional, and structural remodeling of the heart. Nature Communications, 2023, 14 (1), pp.3835. ⟨10.1038/s41467-023-39590-3⟩. ⟨hal-05345765⟩
111 Consultations
90 Téléchargements

Altmetric

Partager

  • More