Communication Dans Un Congrès Année : 2025

Novel nanocomposite thin films by pulsed laser processes for plasmonic based sensing of cancer markers

Résumé

This communication presents the development by pulsed laser deposition processes, of a novel nanocomposite thin film architecture as a highly sensitive plasmonic platform for rapid and early-stage disease diagnosis. The bio-detection principle is based on surface plasmon polaritons (SPP) existing at the interface between a metallic thin film and a dielectric, aiming to achieve high sensitivities and detect small analytes in very low concentrations (lower than fM concentration). Nanocomposite thin films are deposited on a glass substrate and are constituted of an ultra-thin (12 nm) Al2O3 matrix with embedded silver nanoparticles (diameter 2.3 nm), covered by a 48 nm gold layer. This architecture, combining localized surface plasmon resonance (LSPR) in nanoparticles with propagating SPR that exists in the gold film in a single material, can result in enhanced sensitivities. These plasmonic nanocomposites were made in a single reactor coupling two laser processes and developed by our group [1]. The well-known Pulsed Laser Deposition (PLD) method enables the deposition of thin films (Al2O3 matrix and gold upper layer) with high quality and offers the possibility to manage accurately their thicknesses. The associated free cluster generator developed for nanoparticles (NPs) synthesis with a diameter in the range 1-10 nm with quasi-monodisperse size distribution is used for silver NPs fabrication. A specific detection method based on lateral position shift of the reflected wave, known as Goos-Hänchen (GH) shift applied to this highly performing material results in high detection levels, with an ultra-high sensitivity up to 3.3×108 nm.RIU-1. The detection of cancer markers in sub-attomole concentrations was achieved, demonstrating the excellent potentials of the architecture for sensing with the highest detection level ever reached [2]. It is important to emphasize that these fully biocompatible sensors do not require functionalization before detection tests, making them easier to use compared to other platforms. This work was partially supported by the LabEx SigmaLim ANR-10-LBX-0074-01, laboratory of excellence launched by the French Ministry of Higher Education and Research between the XLIM and IRCER Research Institutes. [1] M. Gaudin et al., « A dual nanosecond-pulsed laser setup for nanocomposite synthesis—Ag nanoparticles in Al2O3/VO2 matrix », J. Appl. Phys., vol. 125, no 5, p. 054301, févr. 2019, doi: 10.1063/1.5058107. [2] S. Zhu et al., « Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic nanomaterials », Light Sci. Appl., vol. 13, no 1, p. 2, janv. 2024, doi: 10.1038/s41377-023-01345-6.

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Dates et versions

hal-05322219 , version 1 (20-10-2025)

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  • HAL Id : hal-05322219 , version 1

Citer

Manon Gireau, Fusheng Du, Joelle Youssef, Georges Humbert, Shuwen Zeng, et al.. Novel nanocomposite thin films by pulsed laser processes for plasmonic based sensing of cancer markers. Plasma Thin Film International Union Meeting, Sep 2025, Antibes, France. ⟨hal-05322219⟩
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