Article Dans Une Revue Nucleic Acids Research Année : 2025

IMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis

Gaoussou Sanou
Guilhem Zeitoun
Taciana Manso
Milad Eidi
Shamsa Batool
Anjana Kushwaha
Myriam Croz
Axel Vaillant
Nika Abdollahi
Maria Georga
Ifigeneia Sider
Turkan Samadova
Patrice Duroux

Résumé

IMGT ® , the international ImMunoGeneTics information system ® , has advanced its comprehensive platform for the analysis of immunoglobulin (IG) and T-cell receptor (TR) genes through the de v elopment of ne w automated and scalable tools. T his article presents major updates aligned with IMGT's three axes of research. Axis I introduces dynamic resources such as IMGT / GeneTables, IMGT / AssemblyComparison, IMGT / CDRL engths, IMGT / MultiGenomeVie w er, enabling real-time access to annotated genomic dat a, and IMGT / St atAssembly to assess quality of IG / TR loci in assemblies. Axis II enhances repertoire analysis with a redesigned IMGT / GeneFrequency tool and new customization features in IMGT / V-QUEST, supporting flexible exploration of IG and TR gene expression. Axis III impro v es the accurate prediction of peptide-MHC thanks to IMGT / RobustpMHC. Additionally, the IMGT knowledge graph and its therapeutic extension, IMGT / mAb-KG, provide semantically str uct ured access to > 100 million immunogenetic triplets, integrating IMGT databases and linking IMGT content to external biomedical resources. These de v elopments promote st andardization, interoperabilit y, and integrative analysis across immunogenetics and clinical applications, reinforcing IMGT's (accessible at https://www.imgt.org ) role as a core reference in the era of FAIR data and personalized medicine.

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hal-05314861 , version 1 (14-10-2025)

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Gaoussou Sanou, Guilhem Zeitoun, Taciana Manso, Milad Eidi, Shamsa Batool, et al.. IMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis. Nucleic Acids Research, 2025, ⟨10.1093/nar/gkaf1024⟩. ⟨hal-05314861⟩
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