IMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis
Résumé
IMGT ® , the international ImMunoGeneTics information system ® , has advanced its comprehensive platform for the analysis of immunoglobulin (IG) and T-cell receptor (TR) genes through the de v elopment of ne w automated and scalable tools. T his article presents major updates aligned with IMGT's three axes of research. Axis I introduces dynamic resources such as IMGT / GeneTables, IMGT / AssemblyComparison, IMGT / CDRL engths, IMGT / MultiGenomeVie w er, enabling real-time access to annotated genomic dat a, and IMGT / St atAssembly to assess quality of IG / TR loci in assemblies. Axis II enhances repertoire analysis with a redesigned IMGT / GeneFrequency tool and new customization features in IMGT / V-QUEST, supporting flexible exploration of IG and TR gene expression. Axis III impro v es the accurate prediction of peptide-MHC thanks to IMGT / RobustpMHC. Additionally, the IMGT knowledge graph and its therapeutic extension, IMGT / mAb-KG, provide semantically str uct ured access to > 100 million immunogenetic triplets, integrating IMGT databases and linking IMGT content to external biomedical resources. These de v elopments promote st andardization, interoperabilit y, and integrative analysis across immunogenetics and clinical applications, reinforcing IMGT's (accessible at https://www.imgt.org ) role as a core reference in the era of FAIR data and personalized medicine.
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