Dendrimers: A Themed Issue in Honor of Professor Donald A. Tomalia on the Occasion of His 85th Birthday for His Outstanding Achievements in Advancing the Field of Dendrimers
Résumé
This Special Issue Reprint is in honor of the creator of dendrimers, Prof. Donald A. Tomalia, on the occasion of his 85th birthday. Prof. Tomalia played a key role in establishing the place of dendrimers in polymer chemistry and in nanosciences. This Reprint displays the recent advances in the field of dendrimers and dendritic structures, with emphasis on diverse biological and pharmaceutical properties, written by many of the major contributors to the field. The first paper, a review, is a reflection on the beginning, past, present, and future of dendrimers in pharmaceutic, medicine, and life science. It is followed by three other reviews about ferrocene-based dendritic drugs inducing the Fenton mechanism to kill cancer cells, dendrimers functionalized with boron clusters for boron neutron capture therapy (BNCT) against cancers, and dendrimers used in vivo as drug carriers. Six research papers describe different types of dendritic structures, such as a large library of amphiphilic Janus dendrimers for the targeted delivery of mRNA and storage of vaccines, dendrons equipped with doxorubicin and an antibody against cancer cells, dendrons forming micelles encapsulating either doxorubicin or different drugs against cancer cells, dendrons cross-linked with polymers to form hydrogels suitable for drug release, and dendrons associated with human serum albumin. Three research papers concern dendrimers against choroidal neovascularization in eyes, protoporphyrin IX, and paclitaxel loaded in dendrimers against cancer cells.
Mots clés
- dendrimer
- Gene delivery
- HPC molecular simulations
- Spectroscopy
- Isothermal titration calorimetry
- Amphiphilic dendrimer
- Human serum albumin
- Thermo-responsive
- Polymer
- Network
- Thermogel
- Hydrogel
- Drug encapsulation
- Micelle
- Tocopherol
- Carbosilane
- Theragnostic
- Cellular uptake
- CNDP
- mRNA delivery vectors
- Amphiphilic dendrimers
- Supramolecular dendrimers
- PEG alternatives
- Janus dendrimers
- Dendrimersomes
- Phenylalanine
- PAMAM
- Basophil activation test
- Drug allergy diagnosis
- Silica nanoparticles
- Dendrimeric antigens
- PAMAM dendrimers
- T-cells
- Reduced vaccine price
- Fenton reaction
- Drug delivery
- Fungal and viral diseases
- Bacterial
- Parasitic
- Cancer
- Anticancer drug
- Metallodrug
- Ferrocene
- Hydroxyl radical
- Simplified preparation and handling
- Plant phenolic acids
- Nanotherapeutics
- Vaccines
- Molecular design principles
- Dendrimersome nanoparticles
- Ionizable Janus dendrimer
- One-component vector
- Boron neutron capture therapy (BNCT)
- Polymeric amphiphiles
- RAFT polymerization
- Cholesterol
- Polyglycerol dendron
- Neovascularization
- Hydroxyl PAMAM dendrimer
- AMD
- Peptide conjugates
- Integrin
- Targeted mRNA delivery
- Dendrimer
- Carborane
- Boron clusters
- Prostate cancer
- Targeted delivery
- Doxorubicin
- Gold nanoparticles
- Dendrons
Domaines
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