Article Dans Une Revue Asian Journal of Research in Medical and Pharmaceutical Sciences Année : 2025

In vivo Pharmacological Evaluation of the Anti-inflammatory and Analgesic Effects of Cola hispida Methanol Leaf Extract and Its Fractions

Résumé

Cola hispida Brenan & Keay (Sterculiaceae), a West African plant used in Nigerian Ethnomedicine for pain and inflammation, was evaluated for its anti-inflammatory and analgesic properties in Wistar rats. The methanol leaf extract (CHME) and its n-hexane (CHHF), ethyl acetate (CHEF), and n-butanol (CHBF) fractions were tested using egg albumin and formalin-induced paw oedema models for anti-inflammatory activity, and formalin-induced pain and acetic acid-induced writhing models for analgesic activity, with diclofenac sodium (50 mg/kg) as the positive control. The ethyl acetate fraction (CHEF) at 400 mg/kg exhibited the most potent anti-inflammatory effect, achieving up to 80% inhibition of paw oedema and significantly reducing white blood cell count and erythrocyte sedimentation rate (p < 0.01). CHME, CHBF, and CHHF also reduced oedema significantly (p < 0.05). Notably, CHBF (200 mg/kg) and CHHF (400 mg/kg) significantly decreased paw licking in the formalin test’s late phase by up to 36% (p < 0.05), while CHEF (200 mg/kg) and CHHF (400 mg/kg) reduced writhing by approximately 45% in the acetic acid test, demonstrating robust peripheral pain relief. CHME showed no toxicity up to 5000 mg/kg in mice. Flavonoids and phenolic acids, abundant in CHEF, likely mediate these effects. These findings validate Cola hispida ’s ethnomedicinal use and highlight its potential as a sustainable alternative to non-steroidal anti-inflammatory drugs, supporting Sustainable Development Goals for health (SDG 3) and biodiversity (SDG 15).

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Dates et versions

hal-05280329 , version 1 (24-09-2025)

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  • HAL Id : hal-05280329 , version 1

Citer

Njideka Ifeoma Ani, Nkoyo Imelda Nubilla, Goodnews Onyedikachi Ikeh, Jude Kosisochukwu Onyia, Vincent Uchechukwu Ude, et al.. In vivo Pharmacological Evaluation of the Anti-inflammatory and Analgesic Effects of Cola hispida Methanol Leaf Extract and Its Fractions. Asian Journal of Research in Medical and Pharmaceutical Sciences, 2025, 14 (4), pp.49-69. ⟨hal-05280329⟩
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