Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila
Résumé
An animal’s feeding state changes its behavioral priorities and thus influences even nonfeeding-related decisions. How the feeding state information is transmitted to nonfeeding-related circuits and what circuit mechanisms are involved in biasing nonfeeding-related decisions remain open questions. By combining calcium imaging, neuronal manipulations, behavioral analysis and computational modeling, we determined that the competition between different aversive responses to mechanical cues is biased by changes in the feeding state. We found that this effect is achieved by the differential modulation of two different types of reciprocally connected inhibitory neurons promoting opposing actions. This modulation results in a more frequent active type of response and, less frequently, a protective type of response if larvae are fed sugar than when they are fed a balanced diet. Information about the internal state is conveyed to inhibitory neurons through homologs of the vertebrate neuropeptide Y, which is known to be involved in regulating feeding behavior.
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Cite 10.5281/zenodo.10959533 Jeu de données Jovanic, T., & Manceau, D. (2025). Feeding-state dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila [Data set]. Zenodo. https://doi.org/10.5281/ZENODO.10959533
All data supporting the findings of this study are available within the paper, its Supplementary Information, as source data, and/or within the repository
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Cite swh:1:dir:3f06d6d731741c4beebe901f5ef0b909c8b0b6bd Logiciel
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