Article Dans Une Revue RSC Advances Année : 2025

Cu/Pd dual catalyzed stereoselective construction of vicinal tri- and tetrasubstituted stereocenters connected to chiral α-arylacetonitriles

Résumé

Herein, we report an optimized Pd/Cu bimetallic catalyst that facilitates the stereoselective allylic alkylation of secondary and tertiary nitriles under mild conditions. This method affords homoallylic nitriles with adjacent tri- and tetrasubstituted stereocenters. Using both racemic and enantioselective catalysts, the system exhibits high regio- and enantioselectivity (ee up to 91%). Mechanistic studies and DFT calculations highlight the key synergistic roles of Pd and Cu in controlling both reactivity and enantioselectivity

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hal-05230336 , version 1 (03-02-2026)

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Liliane Mimoun, Hamdi Sanaa, Florian Heppner, Hélène Gérard, Laurine Réset, et al.. Cu/Pd dual catalyzed stereoselective construction of vicinal tri- and tetrasubstituted stereocenters connected to chiral α-arylacetonitriles. RSC Advances, 2025, 15 (37), pp.30915-30920. ⟨10.1039/d5ra04516a⟩. ⟨hal-05230336⟩
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