Article Dans Une Revue Macromolecules Année : 2025

Aqueous Ring-Opening Polymerization Induced Self-Assembly (ROPISA): Tailoring Anisotropic Nanoparticles Through Amino Acid N-Carboxyanhydrides (NCA) Monomer Selection

Résumé

The synthesis of anisotropic nanoparticles by polymerization-induced self-assembly (PISA) remains challenging yet holds significant potential for biomedical applications. In this context, aqueous ringopening polymerization-induced self-assembly (ROPISA) of N-carboxyanhydrides (NCAs) has emerged as a promising strategy, offering a straightforward route to peptide-based nanomaterials. The present study was undertaken to evaluate the versatility of aqueous ROPISA across a range of NCAs, elucidating how their hydrophobicity and the chemical structure of the lateral chains provide access to nanoparticle anisotropy. A comparative analysis was conducted between NCAs with different protecting groups and those derived from distinct hydrophobic amino acids. Beyond hydrophobicity, the aqueous ROPISA of glycine NCA, phenylalanine NCA and tyrosine NCA revealed the crucial role of additional factors such as the hydrophilic/hydrophobic balance, π-π stacking interactions, and hydrogen bonding in shaping nanoparticle anisotropy. Overall, this work highlights the broad applicability of aqueous ROPISA across a wide range of NCA monomers and its ability to generate tailored anisotropic nanoparticles for advanced applications.

Domaines

Fichier principal
Vignette du fichier
HAL ROPISA Monomères.pdf (5.98 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-05221776 , version 1 (25-08-2025)

Licence

Identifiants

Citer

Hannah Beauseroy, Fatemeh Salimi, Julien Aujard-Catot, Léna Alembik, Sébastien Lecommandoux, et al.. Aqueous Ring-Opening Polymerization Induced Self-Assembly (ROPISA): Tailoring Anisotropic Nanoparticles Through Amino Acid N-Carboxyanhydrides (NCA) Monomer Selection. Macromolecules, 2025, 58 (13), pp.6466-6479. ⟨10.1021/acs.macromol.5c01089⟩. ⟨hal-05221776⟩
102 Consultations
209 Téléchargements

Altmetric

Partager

  • More