Article Dans Une Revue Inorganic Chemistry Année : 2024

A Bioinspired Cu2+-Responsive Magnetic Resonance Imaging Contrast Agent with Unprecedented Turn-On Response and Selectivity

Résumé

Imaging extracellular Cu2+ in vivo is of paramount interest due to its biological importance in both physiological and pathological states. Magnetic resonance imaging (MRI) is a powerful technique to do so. However, the development of efficient MRI contrast agents selective for Cu2+, particularly versus the more abundant Zn2+ ions, is highly challenging. We present here an innovative Cu2+ -responsive MRI contrast agent that contains a bioinspired Cu2+ binding site. This sensor shows a remarkable increase in relaxivity of nearly 400% in the presence of Cu2+, which could be rationalized in terms of an increase in the hydration number of the Ln3+ ion, as demonstrated by spectroscopic and relaxometric studies and supported by density functional theory calculations. Importantly, the system also shows an unprecedented selectivity for Cu2+, in particular over Zn2+. Phantom MRI images were recorded at 9.4 T to highlight the potential of such probes, which lies directly in their bioinspired design.

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hal-05216465 , version 1 (27-08-2025)

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Katharina Zimmeter, Agnès Pallier, Bertrand Vileno, Martina Sanadar, Frédéric Szeremeta, et al.. A Bioinspired Cu2+-Responsive Magnetic Resonance Imaging Contrast Agent with Unprecedented Turn-On Response and Selectivity. Inorganic Chemistry, 2024, 63 (49), pp.23067 - 23076. ⟨10.1021/acs.inorgchem.4c03631⟩. ⟨hal-05216465⟩
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