Article Dans Une Revue UTTAR PRADESH JOURNAL OF ZOOLOGY Année : 2025

Synthesis and Characterization of a New Sulfa-drug Derivative and Application on Cypermethrin-poisoned Domestic Pigeons (Columba livia)

Résumé

This study reports the synthesis and characterization of a novel sulfa-drug derivative based on sulfapyridine and piperonal, and its application in mitigating cypermethrin-induced toxicity in domestic pigeons (Columba livia). A computational ADMET analysis was conducted to predict pharmacokinetic and toxicological properties. In vivo experiments were conducted to assess the protective effect of the synthesized compound against cypermethrin toxicity, using parameters such as LD50 determination and measuring the levels of interleukin biomarkers (IL-6, IL-10) in cypermethrin-exposed pigeons. Results indicated that the synthesized derivative reduces cypermethrin-induced mortality, lowers levels of the pro-inflammatory cytokine IL-6, and elevates levels of the anti-inflammatory cytokine IL-10, suggesting a modulation of the inflammatory response and a protective effect against pesticide-induced tissue damage. thoroughly characterized using FT-IR, ¹H-NMR, and ¹³C-NMR spectroscopy. The FT-IR spectrum confirmed the presence of key functional groups, including broad N–H stretching bands, strong imine (C=N) absorption at 1625 cm⁻¹, and characteristic S=O, C–O–C, and C–S vibrations, supporting the formation of sulfonamide and benzodioxole moieties, ¹H-NMR analysis revealed distinct signals corresponding to aromatic protons, methylenedioxy groups, aliphatic methylene units adjacent to heteroatoms, and sulfonamide N–H protons, while the absence of aldehydic signals confirmed complete reaction of the starting aldehyde, ¹³C-NMR spectroscopy further validated the molecular structure through chemical shifts associated with imine carbons (160–170 ppm), aromatic systems (120–140 ppm), oxygen-linked carbons (90–110 ppm), and nitrogen-bound carbons (~40 ppm). Collectively, the spectral data confirm the successful synthesis of the target compound, incorporating an imine linkage, sulfonamide functionality, and a benzodioxole ring, with no residual aldehyde detected. The results suggest that the synthesized derivative exhibits potential pharmacological activity and offers a protective effect against pesticide-induced tissue damage in pigeons. This research focuses on understanding the pathophysiological effects of pyrethroid-class insecticides. Also, it opens new horizons for future studies on the development of new sulfa-derived protective agents and treatments against environmental toxins.

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Dates et versions

hal-05169275 , version 1 (18-07-2025)

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  • HAL Id : hal-05169275 , version 1

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Ansam S.Al-Ahmed, Adel J Hussein, Wasfi A Al-Masoudi, Sawsan A Ali. Synthesis and Characterization of a New Sulfa-drug Derivative and Application on Cypermethrin-poisoned Domestic Pigeons (Columba livia). UTTAR PRADESH JOURNAL OF ZOOLOGY, 2025, 46 (13), pp.183-197. ⟨hal-05169275⟩
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