Article Dans Une Revue Advances in Research on Teaching Année : 2025

Modeling Molecular Interactions with Hyper-Networks and Super-Hyper-networks

Résumé

Graph theory examines the structure of networks by treating entities as vertices and the connections between them as edges. A Hyper-Graph enhances this framework by permitting a single Hyper-edge to link multiple vertices at once. Building on that idea, a Super-Hyper-Graph introduces layers of recursively nested powersets, which create hierarchical and self-referential relationships among its Hyper-edges. These extended models—often called Hyper-Networks and Super-Hyper-networks—capture complex, higher-order associations that ordinary graphs cannot. Such constructions find important applications in the life sciences. For example, a Molecular Interaction Network represents biochemical systems by assigning each molecule to a node and using edges to denote pairwise interactions or chemical reactions, thereby facilitating the analysis of intricate molecular pathways. In this paper, we extend the concept of Molecular Interaction Networks by proposing two new frameworks: the Molecular Interaction Hyper-network and the Molecular Interaction Super-Hyper-network, both grounded in the structures of Hyper-Networks and Super-Hyper-networks. These frameworks offer new insights into multi-scale biochemical systems, with potential applications in drug target identification and pathway analysis. We hope that future research will further explore the mathematical, biological, and computational aspects of the Molecular Interaction Hyper-network and the Molecular Interaction Super-Hyper-network.

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Dates et versions

hal-05157368 , version 1 (11-07-2025)

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  • HAL Id : hal-05157368 , version 1

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Takaaki Fujita, Muhammad Gulistan, Arkan A Ghaib. Modeling Molecular Interactions with Hyper-Networks and Super-Hyper-networks. Advances in Research on Teaching, 2025, 26 (4), pp.294-326. ⟨hal-05157368⟩
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