Article Dans Une Revue Journal of Advances in Medicine and Medical Research Année : 2025

Hypothalamic Obesity Reduces of Orthodontic Tooth Movement and Causes Alterations in the Dental Pulp of Female Rats

Résumé

Aims: To evaluate whether hypothalamic obesity, when associated with induced tooth movement, can influence the histological structure of the dental pulp in rats. Type of Study: Experimental research. Methodology: Forty female pups of Wistar rats were obtained from the Central Animal Facility of the Western Paraná State University. Twenty pups received daily subcutaneous injections of monosodium glutamate (4 g/kg/day) in the cervical region during the first five days of life to induce obesity (MSG group). The remaining twenty animals received injections of hyperosmotic saline solution (1.25 g/kg/day) and served as the non-obese control group (CTL). The animals were then divided into four experimental groups (n = 10/group): Group 1: Non-obese rats not subjected to induced tooth movement (CTL); Group 2: Non-obese rats subjected to induced tooth movement (CTL + ITM); Group 3: Obese rats not subjected to induced tooth movement (MSG); Group 4: Obese rats subjected to induced tooth movement (MSG + ITM). At 97 days, all animals were weighed and euthanized. Results: Obese animals in the MSG+ITM group exhibited a higher Lee index and increased retroperitoneal and perigonadal fat deposits compared to the CTL+ITM group (P < 0.05). They also showed a lower rate of tooth movement than the non-obese animals in the CTL+ITM group (P<0.05). Furthermore, obese animals subjected to tooth movement (MSG+ITM) demonstrated more frequent occurrences of mild inflammatory infiltrate, increased cellularity, and dystrophic and hemodynamic changes compared to the other groups. Conclusion: Hypothalamic obesity associated with induced tooth movement leads to reduced tooth movement and increased occurrences of inflammatory infiltrate, as well as dystrophic and hemodynamic changes in the dental pulp.

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Dates et versions

hal-05130437 , version 1 (26-06-2025)

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Janaina Ahmann Spenassatto, Isabela Zibetti, Alexandre Lopes Paes, Camylle Magalhães Martins, Elaine Manoela Porto, et al.. Hypothalamic Obesity Reduces of Orthodontic Tooth Movement and Causes Alterations in the Dental Pulp of Female Rats. Journal of Advances in Medicine and Medical Research, 2025, 37 (6), pp.217-227. ⟨10.9734/jammr/2025/v37i65864⟩. ⟨hal-05130437⟩
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