Article Dans Une Revue European Journal of Organic Chemistry Année : 2025

Synthesis of Pyrrolidin‐3‐Ones and Spiropyrrolidinones by 1,3‐Dipolar Cycloadditions of Nitrones with Allenylphosphonates

Résumé

A general and effective (3 + 2) cycloaddition reaction between nitrones and allenes to synthesize fluoro‐phosphonopyrrolidin‐3‐ones, as well as spiropyrrolidin‐3‐one phosphonates is reported under microwave heating. The products have been isolated in moderate to good yields and exclusively as 4,5‐trans diastereoisomers in all transformations.

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hal-05093665 , version 1 (02-06-2025)

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Rayhane Hammami, Lucas Mele, Soufiane Touil, David Virieux, Jean‐françois Poisson, et al.. Synthesis of Pyrrolidin‐3‐Ones and Spiropyrrolidinones by 1,3‐Dipolar Cycloadditions of Nitrones with Allenylphosphonates. European Journal of Organic Chemistry, 2025, 28 (27), ⟨10.1002/ejoc.202500390⟩. ⟨hal-05093665⟩
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