Article Dans Une Revue Angewandte Chemie International Edition Année : 2025

Stereocontrol in Conformationally Stable C(sp2)─C(sp3) Atropisomers

Résumé

We report a two-step sequence for the enantioselective construction of a rare family of stable C(sp2)─C(sp3) atropisomers featuring two additional stereogenic centers. The process begins with an organocatalyzed dihydrobenzofurannulation that establishes and controls the stereochemistry of two carbon centers, followed by a highly diastereoselective functionalization that significantly enhances the barrier to diastereomerization of the C(sp2)─C(sp3) bond, effectively locking and stabilizing its configuration.

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hal-05085397 , version 1 (26-05-2025)

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Antoine Domain, Guishun Bai, Juan‐carlos Castillo, Hassane Moussa Abdraman, Stéphane Humbel, et al.. Stereocontrol in Conformationally Stable C(sp2)─C(sp3) Atropisomers. Angewandte Chemie International Edition, 2025, ⟨10.1002/anie.202506810⟩. ⟨hal-05085397⟩
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