Stereocontrol in Conformationally Stable C(sp2)─C(sp3) Atropisomers
Résumé
We report a two-step sequence for the enantioselective construction of a rare family of stable C(sp2)─C(sp3) atropisomers featuring two additional stereogenic centers. The process begins with an organocatalyzed dihydrobenzofurannulation that establishes and controls the stereochemistry of two carbon centers, followed by a highly diastereoselective functionalization that significantly enhances the barrier to diastereomerization of the C(sp2)─C(sp3) bond, effectively locking and stabilizing its configuration.
| Origine | Publication financée par une institution |
|---|---|
| Licence |