Article Dans Une Revue Current Osteoporosis Reports Année : 2023

Cranial Neural Crest Cells Contribution to Craniofacial Bone Development and Regeneration

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Purpose of Review

This review aims to summarize (i) the latest evidence on cranial neural crest cells (CNCC) contribution to craniofacial development and ossification; (ii) the recent discoveries on the mechanisms responsible for their plasticity; and (iii) the newest procedures to ameliorate maxillofacial tissue repair. Recent Findings CNCC display a remarkable differentiation potential that exceeds the capacity of their germ layer of origin. The mechanisms by which they expand their plasticity was recently described. Their ability to participate to craniofacial bone development and regeneration open new perspectives for treatments of traumatic craniofacial injuries or congenital syndromes. Summary These conditions can be life-threatening, require invasive maxillofacial surgery and can leave deep sequels on our health or quality of life. With accumulating evidence showing how CNCC-derived stem cells potential can ameliorate craniofacial reconstruction and tissue repair, we believe a deeper understanding of the mechanisms regulating CNCC plasticity is essential to ameliorate endogenous regeneration and improve tissue repair therapies.

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Dates et versions

hal-05048451 , version 1 (27-04-2025)

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Piera Smeriglio, Antoine Zalc. Cranial Neural Crest Cells Contribution to Craniofacial Bone Development and Regeneration. Current Osteoporosis Reports, 2023, 21 (5), pp.624-631. ⟨10.1007/s11914-023-00804-8⟩. ⟨hal-05048451⟩
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