Article Dans Une Revue Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2025

Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification

Tim d'Aoust
Santiago Clocchiatti-Tuozzo
  • Fonction : Auteur
Cyprien A Rivier
  • Fonction : Auteur
Tsuyoshi Hachiya
  • Fonction : Auteur
Benjamin Grenier-Boley
  • Fonction : Auteur
Vincent Bouteloup
Cecile Proust Lima
Cecilia Samieri
Jeanne Neuffer
Muralidharan Sargurupremraj
  • Fonction : Auteur
Genevieve Chene
Catherine Helmer
Mura Thibault
  • Fonction : Auteur
Philippe Amouyel
  • Fonction : Auteur
Jean-Charles Lambert
  • Fonction : Auteur
Yoichiro Kamatani
  • Fonction : Auteur
David-Alexandre Tregouet
Michael Inouye
  • Fonction : Auteur
Guido J Falcone
  • Fonction : Auteur
Stephanie Debette

Résumé

INTRODUCTION: An integrative polygenic risk score (iPRS) capturing the neurodegenerative and vascular contribution to dementia could identify high-risk individuals and improve risk prediction. METHODS: We developed an iPRS for dementia (iPRS-DEM) in Europeans (aged 65+), comprising genetic risk for Alzheimer's disease (AD) and 23 vascular or neurodegenerative traits (excluding apolipoprotein E [APOE]). iPRS-DEM was evaluated across cohorts comprising older community-dwelling people (N = 3702), a multi-ancestry biobank (N = 130,797 Europeans; 105,404 non-Europeans), and dementia-free memory clinic participants (N = 2032). RESULTS: iPRS-DEM was associated with dementia risk independently of APOE in the elderly (subdistribution hazard ratio [sHR](per1SD )= 1.15, 95% confidence interval [CI]: 1.03 to 1.28), which generalized to Europeans (EUR-sHR(per1SD )= 1.28, 95% CI: 1.09 to 1.51]), East-Asians (EAS-sHR(per1SD )= 5.29, 95% CI: 1.43 to 34.36), and memory-clinic participants (sHR(per1SD )= 1.25, 95% CI: 1.11 to 1.42). Prediction was comparable to clinical risk factors in older community-dwelling people, with improved performance among memory-clinic patients. Risk stratification was enhanced by defining four genetic risk groups with iPRS-DEM and APOE epsilon 4, reaching five-fold increased risk in APOE epsilon 4+/iPRS-DEM+ memory-clinic participants. DISCUSSION: Alongside APOE epsilon 4, iPRS-DEM may refine risk stratification for the enrichment of dementia clinical trials and prevention programs. Highlights iPRS-DEM reflects neurodegenerative and vascular contribution to dementia. We show iPRS-DEM captures additional dementia genetic risk beyond APOE and AD-PRS. iPRS-DEM, in combination with APOE epsilon 4, shows promise for dementia risk stratification. Our results generalize across both population-based and memory-clinic settings. We show transportability of iPRS-DEM to East Asian ancestry.

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hal-05045641 , version 1 (24-04-2025)

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Tim d'Aoust, Santiago Clocchiatti-Tuozzo, Cyprien A Rivier, Aniket Mishra, Tsuyoshi Hachiya, et al.. Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025, 21 (3), pp.e70014. ⟨10.1002/alz.70014⟩. ⟨hal-05045641⟩
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