Article Dans Une Revue New Journal of Chemistry Année : 2024

Ciprofloxacin as a tryptophan mimic within an antimicrobial peptide

John R F B Connolly
Deirdre Fitzgerald-Hughes
Jimmy Muldoon
Marc Devocelle

Résumé

Ciprofloxacin has been used to replace tryptophan at positions 3 and 6 in the antimicrobial peptide (AMP) Bac8c. Bac8c(Cip 3,6 ) showed comparable antimicrobial activity but increased selectivity toward some Gram-negative bacteria with MIC values of r6.25 lM. 3,6 ) was also non-cytotoxic to cultured HepG2 cells at antimicrobial concentrations, with a CC 50 4300 lM.

Bac8c(Cip

Fichier principal
Vignette du fichier
Connolly et al., 2024 (AMPs conjugated Ciprofloxacin)(New J Chem).pdf (1.15 Mo) Télécharger le fichier
Origine Publication financée par une institution
Licence

Dates et versions

hal-04951838 , version 1 (17-02-2025)

Licence

Identifiants

Citer

John R F B Connolly, Deirdre Fitzgerald-Hughes, Marc Maresca, Jimmy Muldoon, Marc Devocelle. Ciprofloxacin as a tryptophan mimic within an antimicrobial peptide. New Journal of Chemistry, 2024, 48, pp.15722 - 15725. ⟨10.1039/d4nj01445f⟩. ⟨hal-04951838⟩
64 Consultations
97 Téléchargements

Altmetric

Partager

  • More