Ciprofloxacin as a tryptophan mimic within an antimicrobial peptide
Résumé
Ciprofloxacin has been used to replace tryptophan at positions 3 and 6 in the antimicrobial peptide (AMP) Bac8c. Bac8c(Cip 3,6 ) showed comparable antimicrobial activity but increased selectivity toward some Gram-negative bacteria with MIC values of r6.25 lM. 3,6 ) was also non-cytotoxic to cultured HepG2 cells at antimicrobial concentrations, with a CC 50 4300 lM.
Bac8c(Cip
Domaines
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Connolly et al., 2024 (AMPs conjugated Ciprofloxacin)(New J Chem).pdf (1.15 Mo)
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