Pré-Publication, Document De Travail Année : 2025

Magnetic Field-Induced Drug Delivery from ZIF-8 Metal-Organic Frameworks-Based Nanocomposites through Magnetic Nanoparticles Heating or Motion

Ahmed Abdelhamid
  • Fonction : Auteur
Aitor Alvarez
  • Fonction : Auteur
Loubna Laib
  • Fonction : Auteur
Pascal Clerc
  • Fonction : Auteur
Manuel Ceballos
  • Fonction : Auteur
Justine Journaux
  • Fonction : Auteur
Anil Misra
Mohammad S Alavijeh
  • Fonction : Auteur
Géraldine Ballon
Corinne Bousquet
  • Fonction : Auteur
Beatriz Pelaz
  • Fonction : Auteur
Pablo del Pino
Julian Carrey

Résumé

Metal-organic frameworks (MOFs) hold great promise for drug delivery applications due to their large tunable porosity and structural flexibility, which facilitate designs with high drug-loading capacities and biocompatibility. Despite these advantages, controlling off-target, uncontrolled drug release remains challenging. This study develops a magnetic field-responsive magnetic nanocomposite based on MOFs to enable spatiotemporal controlled drug delivery. The design features a superparamagnetic iron oxide nanoparticle core and a nanometric zeolitic imidazolate framework (ZIF-8) shell, loaded with cresyl violet as a fluorescent probe and stabilized with a fluorescein-labelled amphiphilic polymer. The nanocomposites demonstrate biocompatibility up to 1 pM with MiaPaCa-2 cancer cells and cancerassociated fibroblasts (CAF) and preferentially accumulate in endolysosomes. Exposure to high-frequency alternating or low-frequency rotating magnetic fields significantly increases the release of cresyl violet into the cytosol of MiaPaca-2 and CAF cells. This release -whether thermal or mechanical-reduces the viability of cells in 2D culture and the size of 3D spheroids composed of MiaPaCa2 and CAF cells, illustrating precise spatiotemporal control over the drug delivery process. The proposed MOF-based magnetic nanocomposites represent promising platforms for developing magnetic field-responsive drug delivery systems.

Fichier principal
Vignette du fichier
magnetic-field-induced-drug-delivery-from-zif-8-metal-organic-frameworks-based-nanocomposites-through-magnetic-nanoparticles-heating-or-motion.pdf (1.56 Mo) Télécharger le fichier

Dates et versions

hal-04943625 , version 1 (12-02-2025)

Licence

Identifiants

Citer

Ahmed Abdelhamid, Aitor Alvarez, Loubna Laib, Pascal Clerc, Manuel Ceballos, et al.. Magnetic Field-Induced Drug Delivery from ZIF-8 Metal-Organic Frameworks-Based Nanocomposites through Magnetic Nanoparticles Heating or Motion. 2025. ⟨hal-04943625⟩
210 Consultations
204 Téléchargements

Partager

  • More