Article Dans Une Revue Cancer Informatics Année : 2019

Separating the Local and Malignant Dimensions of Cancer Adaptation

Résumé

The repeatability observed across cancers arising in the same tissue can help understand the evolutionary process of tumour initiation. We recently developed a framework to quantify the local malignant adaptation of genetic clones in tissue-specific environments. In this Commentary, we argue that such a 1-dimensional model can be improved by separating its 2 components to obtain a dual scale: local adaptation, dictating proliferation rates in the local environment, and malignant adaptation, influencing the likelihood that a clone becomes cancerous and invasive. Such a change could strengthen our understanding of the population dynamics underlying cancer initiation and assess different evolutionary scenarios.

Domaines

Fichier principal
Vignette du fichier
10.1177_1176935119872954.pdf (1.49 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04934927 , version 1 (07-02-2025)

Licence

Identifiants

Citer

Benjamin Roche, Pierre Martinez. Separating the Local and Malignant Dimensions of Cancer Adaptation. Cancer Informatics, 2019, 18, pp.1176935119872954. ⟨10.1177/1176935119872954⟩. ⟨hal-04934927⟩
64 Consultations
41 Téléchargements

Altmetric

Partager

  • More