Article Dans Une Revue CHILDREN-BASEL Année : 2024

Left Ventricular Longitudinal Strain Abnormalities in Childhood Exposure to Anthracycline Chemotherapy

Arnaud Rique
  • Fonction : Auteur
Jennifer Cautela
  • Fonction : Auteur
Franck Thuny
Gerard Michel
  • Fonction : Auteur
Fedoua El Louali
  • Fonction : Auteur

Résumé

Current mortality is low in cases of childhood acute leukemia. Dilated cardiomyopathy induced by anthracyclines remains the main cause of morbidity and mortality during mid-term and long-term follow-up. The aim of our study was to analyze the profile of left ventricular alterations in children treated with anthracyclines and to analyze risks and protective factors, including physical activity. Children and young adults with acute leukemia treated with anthracyclines between 2000 and 2018 during childhood were included. The physical activity performed by the patients before and after treatment was quantified in metabolic equivalent tasks, MET.h, per week. An echocardiographic assessment was performed, including strain analysis. Thirty-eight patients with a median age of 5 [3–8] years were included. Dilated cardiomyopathy was diagnosed in 3 patients and longitudinal strain abnormalities were observed in 11 patients (28.9%). Radiotherapy, cumulative anthracycline doses > 240 mg/m2, and the practice of physical activity > 14 MET.h per week (after leukemia treatment) were independently associated with strain abnormalities. In multivariate analysis, radiotherapy was significantly associated with an increased risk of LV GLS abnormalities (OR = 1.26 [1.01–1.57], p = 0.036), and physical activity > 14 MET.h/week after oncological treatment was significantly associated with a reduction in the risk of LV GLS abnormalities (OR of 0.03 [0.002–0.411], p = 0.009). The strain assessment of left ventricular function is an interesting tool for patient follow-up after leukemia treatment. Moderate and steady physical activity seems to be associated with fewer longitudinal strain abnormalities in patients treated with anthracyclines during childhood.

Fichier principal
Vignette du fichier
Left_Ventricular_Longitudinal_Strain_Abnormalities2025.pdf (427.37 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Licence

Dates et versions

hal-04931269 , version 1 (14-04-2025)

Licence

Identifiants

Citer

Arnaud Rique, Jennifer Cautela, Franck Thuny, Gerard Michel, Caroline Ovaert, et al.. Left Ventricular Longitudinal Strain Abnormalities in Childhood Exposure to Anthracycline Chemotherapy. CHILDREN-BASEL, 2024, 11 (3), ⟨10.3390/children11030378⟩. ⟨hal-04931269⟩

Collections

57 Consultations
70 Téléchargements

Altmetric

Partager

  • More