Reaction of phenylacetate enolates with γ- bromo α,β-unsaturated derivatives: diastereo-and enantioselective allylic substitution
Résumé
The reaction of Li t.butyl phenylacetate enolate with γ-bromo-α,β-unsaturated esters 1a,b is regio-and stereoselective. Asymmetric synthesis can be performed with a chiral ester 1d. With amide 1c, the regio-and stereoselectivity are poor.