Article Dans Une Revue Analytical Chemistry Année : 2013

Fine control over the size of surfactant-polyelectrolyte nanoparticles by hydrodynamic flow focusing

Résumé

Synthesis of surfactant-polyelectrolyte nanoparticles was carried out in a microfluidic device with a fine control over the size and the polydispersity. An anionic polysaccharide (sodium carboxymethylcellulose, CMC) solution was focused using a cationic surfactant (dodecyl trimethylammonium bromide, DTAB) solution in a microfluidic channel at selected ratios of flow rates and reagent concentrations. The methodology ensured a controlled mixing kinetics and a uniform distribution of charges at the mixing interface. The resulting nanoparticles exhibited remarkably well-defined and repeatable size distributions, with hydrodynamic diameters tunable from 50 up to 300 nm and polydispersity index around 0.1 in most cases. Microfluidic-assisted self-assembly may be an efficient way to produce well-controlled polyelectrolyte-based nanoparticles suitable for colloidal science as well as for gene delivery applications.

Fichier non déposé

Dates et versions

hal-04882940 , version 1 (13-01-2025)

Identifiants

Citer

Guillaume Tresset, Catalin Marculescu, Anniina Salonen, Ming Ni, Ciprian Iliescu. Fine control over the size of surfactant-polyelectrolyte nanoparticles by hydrodynamic flow focusing. Analytical Chemistry, 2013, 85 (12), pp.5850-5856. ⟨10.1021/ac4006155⟩. ⟨hal-04882940⟩
68 Consultations
0 Téléchargements

Altmetric

Partager

  • More