Prior SARS-CoV-2 infection enhances and reshapes spike protein–specific memory induced by vaccination - Archive ouverte HAL
Article Dans Une Revue Science Translational Medicine Année : 2023

Prior SARS-CoV-2 infection enhances and reshapes spike protein–specific memory induced by vaccination

Véronique Barateau
Loïc Peyrot
Carla Saade
Bruno Pozzetto
Karen Brengel-Pesce
Mad-Hélénie Elsensohn
  • Fonction : Auteur
Omran Allatif
Nicolas Guibert
Christelle Compagnon
  • Fonction : Auteur
Natacha Mariano
Julie Chaix
  • Fonction : Auteur
Sophia Djebali
Jean-Baptiste Fassier
Bruno Lina
  • Fonction : Auteur
Katia Lefsihane
  • Fonction : Auteur
Maxime Espi
Olivier Thaunat
Manuel Rosa-Calatrava
Andres Pizzorno
Laetitia Henaff
  • Fonction : Auteur
Mitra Saadatian-Elahi
Philippe Vanhems
  • Fonction : Auteur
Thierry Walzer
Sophie Trouillet-Assant
Thierry Defrance

Résumé

The diversity of vaccination modalities and infection history are both variables that have an impact on the immune memory of individuals vaccinated against SARS-CoV-2. To gain more accurate knowledge of how these parameters imprint on immune memory, we conducted a long-term follow-up of SARS-CoV-2 spike protein–specific immune memory in unvaccinated and vaccinated COVID-19 convalescent individuals as well as in infection-naïve vaccinated individuals. Here, we report that individuals from the convalescent vaccinated (hybrid immunity) group have the highest concentrations of spike protein–specific antibodies at 6 months after vaccination. As compared with infection-naïve vaccinated individuals, they also display increased frequencies of an atypical mucosa-targeted memory B cell subset. These individuals also exhibited enhanced T H 1 polarization of their SARS-CoV-2 spike protein–specific follicular T helper cell pool. Together, our data suggest that prior SARS-CoV-2 infection increases the titers of SARS-CoV-2 spike protein–specific antibody responses elicited by subsequent vaccination and induces modifications in the composition of the spike protein–specific memory B cell pool that are compatible with enhanced functional protection at mucosal sites.

Dates et versions

hal-04872918 , version 1 (08-01-2025)

Identifiants

Citer

Véronique Barateau, Loïc Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, et al.. Prior SARS-CoV-2 infection enhances and reshapes spike protein–specific memory induced by vaccination. Science Translational Medicine, 2023, 15 (687), ⟨10.1126/scitranslmed.ade0550⟩. ⟨hal-04872918⟩
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