The rain regime in the Eastern Mediterranean is primarily controlled by Mediterranean winter cyclonic systems. The density, chemical composition and relative volume of the Dead Sea responds sensitively to hydrological changes, and can be used to track the evolution of the Mediterranean hydroclimate during the late Quaternary. Halite fluid inclusions are exquisite aliquots of the lake brine, and can therefore be used to reconstruct these variables. Here, we reconstruct the Dead Sea lake density at 25 °C and 1 atmosphere from the measured sound velocity in halite fluid inclusions (FIs) of the deep ICDP core 5017-1-A during Marine Isotope Stages (MIS) 7c, 7a, 5e and 5c. Combining the density data with published pore fluid chemical composition data and evaporation simulations with the software PhreeqC v.3, we reconstruct the lake's chemical composition, relative volume and precipitated halite. The dataset presents values for each FI; averages can be calculated for each sample or group of samples located within a few 10s cm in the core (see paper referenced with this dataset, Guillerm et al., 2023). For each period MIS 7c, 7a, 5e and 5c, the reported lake volume is a value relative to the average of the first (deepest) sample of the given period. Observed and calculated halite thicknesses are cumulated from the beginning of each period MIS 7c, 7a, 5e and 5c.