Efficacy and tolerance of intravenous methylprednisolone pulses in children with severe bronchopulmonary dysplasia requiring respiratory support - Archive ouverte HAL
Article Dans Une Revue Pediatric Pulmonology Année : 2024

Efficacy and tolerance of intravenous methylprednisolone pulses in children with severe bronchopulmonary dysplasia requiring respiratory support

Josseline Reynaud
  • Fonction : Auteur
Lélia Dreyfus
Marine Butin
Isabelle Godbert
  • Fonction : Auteur
Florent Baudin
Côme Horvat
  • Fonction : Auteur

Résumé

Abstract Objectives Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects premature babies and contributes to their morbidity. French BPD guidelines suggest the use of intravenous methylprednisolone pulses (IVMP) for those who require respiratory support (RS) following 36 weeks postmenstrual age (PMA). However, there is scant data on the efficacy and tolerance for this indication. Our objectives were to assess the efficacy and tolerance of IVMP in patients with severe BPD requiring RS. Study and Design This retrospective observational study included preterm infants (<32 weeks gestational age) treated by IVMP between January 2016 and March 2021, in a single tertiary care hospital. The primary endpoint was signified by changes in the Pulmonary Severity Score (PSS). Our secondary endpoints were changes in RS and the tolerance of IVMP. Results Data of 14 children with BPD under RS were reviewed. Their median [IQR] gestational age at birth was (26[26–29.5] weeks). After IVMP administration, the PSS did not improve significantly from baseline day 0 (D0) (0.85[0.55–1.15]) to D7 (0.74 [0.48–1.00]) or Month 1 (1.02 [0.57–1.48]). Three children (21%) experienced a decrease in RS in the following month of IVMP. There was no negative short‐term impact on growth. Five infants presented infectious complications. The development quotient was measured in 5 children at 2 years of age. Conclusion In our study, IVMP did not improve PSS and it was associated with a high number of infections. Other studies are needed to better define the place of IVMP in these infants.

Dates et versions

hal-04834093 , version 1 (12-12-2024)

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Citer

Josseline Reynaud, Lélia Dreyfus, Laurianne Coutier, Marine Butin, Isabelle Godbert, et al.. Efficacy and tolerance of intravenous methylprednisolone pulses in children with severe bronchopulmonary dysplasia requiring respiratory support. Pediatric Pulmonology, 2024, ⟨10.1002/ppul.27344⟩. ⟨hal-04834093⟩
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