Article Dans Une Revue Oral Oncology Année : 2024

Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study

1 Service Oto-Rhino-Laryngologie (ORL) et chirurgie cervico-faciale [CHU Toulouse]
2 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
3 IGR - Institut Gustave Roussy
4 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
5 RMeS - Regenerative Medicine and Skeleton
6 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
7 Service d’Oncologie Médicale [Hôpital de la Timone - APHM]
8 CHU Montpellier = Montpellier University Hospital
9 Hôpital Foch [Suresnes]
10 CHU Nice - Centre Hospitalier Universitaire de Nice
11 CHU de Bordeaux Pellegrin [Bordeaux]
12 Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse
13 HEGP - Hôpital Européen Georges Pompidou [APHP]
14 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
15 ULiège - Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich
16 CHU Rouen
17 CHU Limoges
18 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
19 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
20 CHU Reims - Hôpital universitaire Robert Debré [Reims]
21 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
22 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
23 CHU Pitié-Salpêtrière [AP-HP]
24 CHU Tenon [AP-HP]
25 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
26 CHUGA - CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble
27 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
28 Oncopole Claudius Regaud
29 CRCT - Centre de Recherches en Cancérologie de Toulouse
Joel Castelli
  • Fonction : Auteur
Jonathan Barbut
  • Fonction : Auteur
Philippe Ceruse
  • Fonction : Auteur
Xavier Dufour

Résumé

Locally-advanced stage Totalglossectomy

Materials and methods: This retrospective multicentric study, based on the French national network on rare head and neck cancers (REFCOR), included all patients with a T3-T4 salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018. Results: In total, 47 patients were included, of which 44.7 % underwent surgery. Histologies were mostly adenoid cystic carcinomas (61.7 %), followed by other adenocarcinomas (27.7 %) and mucoepidermoid carcinomas (10.6 %). Median follow-up duration was 63.9 months. In multivariable analysis, surgery was significantly associated with better Recurrence-Free Survival (HR = 0.23, 95 %CI [0.09;0.55]) and Local/Regional Recurrence-Free Survival (HR = 0.31, 95 %CI [0.10;0.95]). The rate of distant metastasis at the end of follow-up was 61.9 % in the surgical group and 57.7 % in the non-surgical group. The Distant Metastasis Free Survival was 54.9 % [38.3;68.7], without statistical difference between both groups. There were similar rates of definitive gastrostomies but the rate of normal oral diet at the last follow-up seemed higher in the surgery group (38.1 % vs 15.4 %). Conclusion: Radical surgery in that population mainly aims to improve local/regional control, which may result in better long-term swallowing functions. About half of these tumors may be associated with occult distant metastasis at initial presentation. More studies are warranted to establish the role of postoperative RT and nonsurgical treatment with concurrent CRT.

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hal-04824410 , version 1 (06-12-2024)

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Valentine Poissonnet, Emilien Chabrillac, Emmanuelle Uro-Coste, Virginie Woisard, Antoine Moya-Plana, et al.. Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study. Oral Oncology, 2024, 159, pp.107072. ⟨10.1016/j.oraloncology.2024.107072⟩. ⟨hal-04824410⟩
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