Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study - Archive ouverte HAL
Article Dans Une Revue Oral Oncology Année : 2024

Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study

Joel Castelli
  • Fonction : Auteur
Claire Castain
  • Fonction : Auteur
Jonathan Barbut
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Haitham Mirghani
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Diane Evrard
  • Fonction : Auteur
Olivier Bouchain
  • Fonction : Auteur
Jean Paul Marie
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Hélène Orliac
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Philippe Ceruse
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Xavier Dufour
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Esteban Brenet
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Audrey Rambeau
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Philippe Herman
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Yazan Abu Shama
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Chloé Bertolus
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Sarah Atallah
  • Fonction : Auteur
Sylvain Morinière
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Christian Righini
  • Fonction : Auteur
François Mouawad
  • Fonction : Auteur
Suzy Duflo
  • Fonction : Auteur
Sébastien Vergez
  • Fonction : Auteur

Résumé

Locally-advanced stage Totalglossectomy

Materials and methods: This retrospective multicentric study, based on the French national network on rare head and neck cancers (REFCOR), included all patients with a T3-T4 salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018. Results: In total, 47 patients were included, of which 44.7 % underwent surgery. Histologies were mostly adenoid cystic carcinomas (61.7 %), followed by other adenocarcinomas (27.7 %) and mucoepidermoid carcinomas (10.6 %). Median follow-up duration was 63.9 months. In multivariable analysis, surgery was significantly associated with better Recurrence-Free Survival (HR = 0.23, 95 %CI [0.09;0.55]) and Local/Regional Recurrence-Free Survival (HR = 0.31, 95 %CI [0.10;0.95]). The rate of distant metastasis at the end of follow-up was 61.9 % in the surgical group and 57.7 % in the non-surgical group. The Distant Metastasis Free Survival was 54.9 % [38.3;68.7], without statistical difference between both groups. There were similar rates of definitive gastrostomies but the rate of normal oral diet at the last follow-up seemed higher in the surgery group (38.1 % vs 15.4 %). Conclusion: Radical surgery in that population mainly aims to improve local/regional control, which may result in better long-term swallowing functions. About half of these tumors may be associated with occult distant metastasis at initial presentation. More studies are warranted to establish the role of postoperative RT and nonsurgical treatment with concurrent CRT.

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hal-04824410 , version 1 (06-12-2024)

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Valentine Poissonnet, Emilien Chabrillac, Emmanuelle Uro-Coste, Virginie Woisard, Antoine Moya-Plana, et al.. Therapeutic strategy for advanced stages salivary carcinomas of the tongue: A multicenter REFCOR study. Oral Oncology, 2024, 159, pp.107072. ⟨10.1016/j.oraloncology.2024.107072⟩. ⟨hal-04824410⟩
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